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Daniel J. Chandler, Ph.D.

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    Assistant Professor

    Science Center 217 


    Drexel University College of Medicine, Ph.D., 2013

Research Interests

Organizational and functional properties of the central monoaminergic projection systems and how they adapt in response to stress


(Updated July 2019)

  1. Prouty EW, Chandler DJ, Gao WJ, Waterhouse BD. Selective vulnerability of dorsal raphe-medial prefrontal cortex projection neurons to corticosterone-induced hypofunction. Eur J Neurosci, 1-15, January 2019
  2. Borodovitsyna O, Flamini MD, Chandler DJAcute Stress Persistently Alters Locus Coeruleus Function and Anxiety-like Behavior in Adolescent Rats. Neuroscience, 373: 7-19, March 2018.
  3. Prouty EW, Chandler DJ, Waterhouse BD. Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons. Brain Res, 1675: 28-40, November 2017.
  4. Prouty EW, Waterhouse BD, Chandler DJCorticotropin releasing factor dose-dependently modulates excitatory synaptic transmission in the noradrenergic nucleus locus coeruleus. Eur J Neurosci, 45(5); 712-22, March 2017.
  5. Waterhouse BD, Chandler DJHeterogeneous organization and function of the central noradrenergic system. Brain Res, 1641(Pt B): v-x, June 2016.
  6. Chandler DJEvidence for a specialized role of the locus coeruleus noradrenergic system in cortical circuitries and behavioral operations. Brain Res, 1641(Pt B): 197-206, June 2016
  7. Chandler DJ, Waterhouse BD, Gao WJ. New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons. Front Neural Circuits, 8(53), 1-10, May 2014.
  8. Chandler DJ, Gao WJ, Waterhouse BD. Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices. Proc Natl Acad Sci, 111(18): 6816-21, May 2014.
  9. Chandler DJSomething's got to give: psychiatric disease on the rise and novel drug development on the decline. Drug Discov Today,18(3-4): 202-6, February 2013.
  10. Chandler DJ, Lamperski CS, WaterhouseBD. Identification and distribution of projections from monoaminergic and cholinergic nuclei to functionally differentiated subregions of prefrontal cortexBrain Res, 1522: 38-58, 2012.