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Sal J. Caradonna, Ph.D.

Professor and Chair

Science Center 124
856 566-6056
Fax: 856 566-6232
caradonn@rowan.edu 

Education

State University of New York at Buffalo, Roswell Park Cancer Institute, NY
Ph.D. (Pharmacology), 1980

Marist College, NY
B.A. (Biology), 1975

Research Interests

Our laboratory has recently changed research direction from studies on dUTP metabolism and base-excision repair to studies involving airway progenitor cell development. We have adopted an air-liquid interface model system to grow and differentiate airway cells derived from the nasal passages. These ex-vivo cultures closely approximate developmental pathways that occur in the human body and are useful for studies on the effects of drugs, vitamins, supplements and environmental toxins. One current project in the lab involves analyzing the effects of e-cigarettes and vaping on the homeostasis and repair capacity of these airway cells exposed to these products.

Recent Publications

  1. Manna VJ, Caradonna SJ. The heterogeneous nature of the Coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia. bioRxiv : the preprint server for biology. 2020 July. doi: https://doi.org/10.1101/2020.07.09.190074.

  2.  Rotoli SM, Caradonna SJ. Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture. J Vis Exp. 2019 May 2;(147). doi: 10.3791/59483. PubMed PMID: 31107447.

  3.  Rotoli SM, Jones JL, Caradonna SJ. Cysteine residues contribute to the dimerization and enzymatic activity of human nuclear dUTP nucleotidohydrolase (nDut). Protein Sci. 2018 Oct;27(10):1797-1809. doi: 10.1002/pro.3481. Epub 2018 Sep 24. PubMed PMID: 30052299; PubMed Central PMCID: PMC6199149.

  4.   Fischer JA, Caradonna SJ. Analysis of Nuclear Uracil DNA-Glycosylase (nUDG) Turnover During the Cell Cycle. Methods Mol Biol. 2017;1524:177-188. doi: 10.1007/978-1-4939-6603-5_11. PubMed PMID: 27815903.

  5.   Jones KL, Roche M, Gantier MP, Begum NA, Honjo T, Caradonna S, Williams BR, Mak J. X4 and R5 HIV-1 have distinct post-entry requirements for uracil DNA glycosylase during infection of primary cells. J Biol Chem. 2010 Jun 11;285(24):18603-14. doi: 10.1074/jbc.M109.090126. Epub 2010 Apr 6. PubMed PMID: 20371602; PubMed Central PMCID: PMC2881786.

Full Biography

https://www.ncbi.nlm.nih.gov/myncbi/14G2dtQCLSkAt/bibliography/public/