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Shawna Rotoli, Ph.D.

headshot of Dr. Shawna RotoliAssistant Professor

Science Center

murphysm@rowan.edu

Education

Rowan University, Stratford, NJ
Ph.D. (Molecular and Cell Biology)

Temple University, Philadelphia, PA
B.S. (Biochemistry)

 

Research Interests

Dr. Rotoli received her Ph.D. in Molecular and Cell Biology from Rowan University. Upon graduation, she received the Outstanding Achievement in Doctoral Research award for her work during her Ph.D. Her thesis research focused on the human dUTPase protein. She characterized the nuclear isoform’s structure and enzymatic function using multiple molecular and biophysical techniques. These studies revealed a potential novel target on the dUTPase protein that may have the potential to be used for the development of an inhibitor. This work also shed light on a post-translational modification that regulates protein activity through its redox potential. She has continued her research training at Rowan University where her current contributions involve characterization of the SARS-CoV-2 receptor, ACE2. While pursuing her research interests she also provided instruction to students pursuing their Masters in Histopathology.

She is currently an Assistant Professor in the Molecular Biology department and is serving as the Co-Director for the Gastroenterology block in PBL I. Dr. Rotoli is an experienced facilitator and is committed to fostering a group dynamic that allows students to take full advantage of the benefits of the independent learning style that is the backbone of PBL.

Recent Publications

  1. Borowczak M, Rotoli S.M, (September 29, 2022) A Qualitative exploration of social support in males and females experiencing issues with fertility. Cureus 14(9): e29763.doi:10.7759/cureus.29763
  2. Borowczak M, Rotoli S.M, (September 19, 2022) Possible Gender Differences in the Level of Perceived social Support in Couples Who Are Experiencing Issues with Infertility. Cureus 14(9):e29343. doi:10.7759/cureus.29343
  3. Rotoli, S.M., Biswas-Fiss E., Biswas S.B. Quantitative Analysis of the mechanism of DNA binding by Bacillus DnaA protein. Biochimie (2012) 94(12):2764-75.
  4. Rotoli, S.M., Jones, J.L., Caradonna, S.J. Cysteine residues contribute to the dimerization and enzymatic activity of human nuclear dUTP nucleotidohydrolase (nDut). Protein Sci (2018)
  5. Rotoli, S.M., Caradonna, S.J. Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture. J Vis Exp. 2019 May 2; (147). doi: 10.3791/59483. PubMed PMID: 31107447.
  6. Manna V.J.,  Choi H., Rotoli, S.M., Caradonna S.J. The dynamic nature of the coronoavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia. BBA Adv. 2022; 2:1000444. doi: 10.1016/j.bbadva.2022.100044. Epub 2022 Feb 12. PubMed PMID: 35187520; PubMed Central PMCID: PMC8840828.