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Lakshman Segar, Ph.D.

Associate Professor

SOO 2952
Phone: 856-566-6056
segar@rowan.edu 

Education

University of Saskatchewan, Saskatoon, SK, Canada
Ph.D. (Pharmacology), 1995

University of Madras, India
M.Sc. (Biochemistry), 1981

Research Interests

Dr. Segar developed his research interests in cardiovascular biology during his doctoral and postdoctoral training programs at the University of Saskatchewan and University of British Columbia (1990-1998). He has utilized in vivo, ex vivo, and/or in vitro model systems to study the molecular mechanisms of cardiac/smooth muscle contractility, atherosclerosis, and neointimal hyperplasia. He serves as a PBL facilitator for the medical students at Rowan-Virtua SOM and as a Biochemistry course instructor for the graduate students at GSBS.

Recent Publications

  1. Pyla, R., Hartney, T.J. and Segar, L. AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle. Journal of Basic and Clinical Physiology and Pharmacology. 2022 (online ahead of print).

  2. Pichavaram, P., Shawky, N. M., Hartney, T.J., Jun, J.Y. and Segar, L. Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice. European Journal of Pharmacology. 2021; 890: 173666.

  3. Donnan, K. and Segar, L. SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes. European Journal of Pharmacology. 2019; 846: 23-29.

  4. Srinivasan, M.P., Shawky, N.M., Kaphalia, B.S., Thangaraju, M. and Segar, L. Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice. Biochemical Pharmacology. 2019; 160: 46-61.

  5. Shawky, N.M. and Segar, L. Sulforaphane improves leptin responsiveness in high-fat high-sucrose diet-fed obese mice. European Journal of Pharmacology. 2018; 835: 108-114.

  6. Osman, I., Fairaq, A. and Segar, L. Pioglitazone attenuates injury-induced neointima formation in mouse femoral artery partially through activation of AMP-activated protein kinase. Pharmacology. 2017; 100: 64-73.
  7. Shawky, N. M. and Segar, L. Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation. Pharmacological Research. 2017; 119: 251-264.

  8. Fairaq, A., Shawky, N. M., Osman, I., Pichavaram, P. and Segar, L. AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: implications toward suppression of neointimal hyperplasia. Pharmacological Research. 2017; 119: 289-302.

Complete list of published work in MyBiliography