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Brian P. Weiser, Ph.D.

Dr. Weiser

Assistant Professor

Science Center 307A
Phone: 856 566-6270; Fax: 856 566-6291
weiser@rowan.edu 

Education

Johns Hopkins University, Baltimore, MD
Postdoc (Pharmacology / Enzymology)

University of Pennsylvania, Philadelphia, PA
Ph.D. (Pharmacology)

Albright College, Reading, PA
B.S. (Biology)

 

Research Interests

The Weiser Lab has two main interests: (1) Understanding how protein-protein interactions affect enzyme activity and (2) Discovering small molecules that can be used therapeutically or to explore protein function. Separate projects currently examine DNA repair complexes and sirtuin deacylases.

replication protein A (RPA), uracil DNA glycosylase (UNG2), sirtuin isoform 2 (SIRT2), proliferating cell nuclear antigen (PCNA), propofol, fluorescence

For a full publication list, visit this URL:

https://www.ncbi.nlm.nih.gov/myncbi/brian.weiser.1/bibliography/public/

Selected Publications

  1. Bi D, Yang J, Hong JY, Parikh P, Hinds N, Infanti J, Lin H, Weiser BP (2020) Substrate-dependent modulation of SIRT2 by a fluorescent probe, 1-aminoanthracene. Biochemistry 59: 3869-3878.
  2. Weiser BP (2020) Analysis of uracil DNA glycosylase (UNG2) stimulation by replication protein A (RPA) at ssDNA-dsDNA junctions. Biochimica et Biophysica Acta- Proteins & Proteomics 1868: 140347. 
  3. Weiser BP, Rodriguez G, Cole PA, Stivers JT (2018) N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Research 46: 7169-7178.
  4. Weiser BP, Stivers JT, Cole PA (2017) Investigation of N-terminal phospho-regulation of uracil DNA glycosylase (UNG2) using protein semisynthesis. Biophysical Journal 113: 393-401.
  5. Weiser BP, Eckenhoff RG (2015) Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. Journal of Biological Chemistry 290: 8559-8568.
  6. Weiser BP, Salari R, Eckenhoff RG, Brannigan G (2014) Computational investigation of cholesterol binding sites on mitochondrial VDAC. Journal of Physical Chemistry B 118: 9852-9860.
  7. Emerson DJ*, Weiser BP*, Psonis J, Liao Z, Taratula O, Fiamengo A, Wang X, Sugasawa K, Smith III AB, Eckenhoff RG, Dmochowski IJ (2013) Direct modulation of microtubule stability contributes to anthracene general anesthesia. Journal of the American Chemical Society 135: 5389-5398. *contributed equally