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Brian P. Weiser, Ph.D.

Assistant Professor

Science Center 307A
856 566-6270
Fax: 856 566-6291 


Johns Hopkins University, Baltimore, MD
Postdoc (Pharmacology / Enzymology)

University of Pennsylvania, Philadelphia, PA
Ph.D. (Pharmacology)

Albright College, Reading, PA
B.S. (Biology)

Research Interests

My lab examines the architecture and function of protein-ligand and protein-protein complexes that are mediated by low-affinity interactions. We use chemical and molecular techniques to quantify and manipulate low-affinity interactions to examine their biochemical relevance. Current projects examine (1) DNA repair protein complexes and (2) neuronal deacylase enzymes.   

replication protein A (RPA), uracil DNA glycosylase (UNG2), sirtuin isoform 2 (SIRT2), proliferating cell nuclear antigen (PCNA), propofol

Selected Publications

1. Weiser BP (2020) Analysis of uracil DNA glycosylase (UNG2) stimulation by replication protein A (RPA) at ssDNA-dsDNA junctions. Biochimica et Biophysica Acta- Proteins & Proteomics 1868: 140347. 

2. Weiser BP, Rodriguez G, Cole PA, Stivers JT (2018) N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions. Nucleic Acids Research 46: 7169-7178.

3. Weiser BP, Stivers JT, Cole PA (2017) Investigation of N-terminal phospho-regulation of uracil DNA glycosylase (UNG2) using protein semisynthesis. Biophysical Journal 113: 393-401.

4. Weiser BP, Eckenhoff RG (2015) Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site. Journal of Biological Chemistry 290: 8559-8568

5. Weiser BP, Bu W, Wong D, Eckenhoff RG (2014) Sites and functional consequence of VDAC-alkylphenol anesthetic interactions. FEBS Letters 588: 4398-4403.

6. Weiser BP, Salari R, Eckenhoff RG, Brannigan G (2014) Computational investigation of cholesterol binding sites on mitochondrial VDAC. Journal of Physical Chemistry B 118: 9852-9860.

7. Emerson DJ*, Weiser BP*, Psonis J, Liao Z, Taratula O, Fiamengo A, Wang X, Sugasawa K, Smith III AB, Eckenhoff RG, Dmochowski IJ (2013) Direct modulation of microtubule stability contributes to anthracene general anesthesia. Journal of the American Chemical Society 135: 5389-5398. *contributed equally

8. Weiser BP, Kelz MB, Eckenhoff RG (2013) In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets. Journal of Biological Chemistry 288: 1279-1285